A Field experiment was conducted to evaluate the influence of sorghum extract concentrations in combination with herbicide application time on weed density and yield of wheat at The University of Agriculture, Peshawar, Pakistan during 2015-16. Hand weeding was more effective among all the treatments for controlling weeds, reducing weeds weight, increasing plant height, produced  longer spikes  and  increased biological yield of wheat. Sorghum extract concentrations, herbicide (Affinity) and application time significantly increased yield and decreased weed density in wheat. Sorghum extract sprayed at 1:5 gave better control of weeds, decreased weeds weight, produced longer spikes and increased biological yield, while taller plants were noted with 1:4 (1 kg sorghum and 3 liter of water). Herbicide (Affinity) at the rate of 1.317 kg ha^-1 resulted in low weed density, reduced weeds weight, longer spike, while taller plants and higher biological yield was observed with weedicide applied at 988g ha^-1. Sorghum extract concentration with combination of herbicide sprayed at tillering stage gave better control of weeds, minimum weed weight, maximum plant height and increased biological yield. It is concluded  that sorghum extract concentration 1:5 with Affinity at 1.317 kg ha^-1 applied at tillering stage is recommended for controlling weeds and obtaining high yield of wheat.